Abstract Background Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs.The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to understand the mechanism of morphine addiction.Previous studies have found a number of chronic morphine-induced adaptive changes
Abstract Background Dengue virus infection results in a broad spectrum of clinical outcomes, ranging from asymptomatic infection through to severe dengue.Although prior infection with another viral serotype, i.e.secondary dengue, is known to be an important factor influencing disease severity, current methods to determine primary versus secondary i
Research in older adults diagnosed RED CLOVER PLUS with rheumatic and musculoskeletal diseases (RMDs) comes with unique challenges, as these patients often face consequences of ageing, such as multimorbidity, polypharmacy, and geriatric syndromes (eg, frailty).In this viewpoint, we highlight various clinical, ethical, regulatory and logistical chal
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive degenerative movement disorder characterized by kinetic tremor, cerebellar gait ataxia, parkinsonism, and cognitive decline.This disorder occurs in both males and females, frequently in families with children who have fragile X syndrome.The clinical features of this disorder, both
As one of the most challenging problems in data management, query processing and optimization are always widely concerned by researchers.However, it is very difficult for traditional techniques to meet the diverse requirements of modern database system due to the needs of hand-tuning for specific workloads and datasets.Inspired by advances in apply